000			03222nam a2200397 a 4500
001			EBC938848
003			MiAaPQ
005			20240120133610.0
006			m o d |
007			cr cn|||||||||
008			111025s2012 njua sb 001 0 eng d
010			_z 2011044253
020			_z9780470878279 (cloth)
020			_a9781118274378 (electronic bk.)
035			_a(MiAaPQ)EBC938848
035			_a(Au-PeEL)EBL938848
035			_a(CaPaEBR)ebr10580300
035			_a(CaONFJC)MIL367371
035			_a(OCoLC)802068199
040			_aMiAaPQ _cMiAaPQ _dMiAaPQ
050		4	_aRS100 _b.D78 2012
082	0	4	_a338.4/76151 _223
245	0	0	_aDrug repositioning _h[electronic resource] : _bbringing new life to shelved assets and existing drugs / _cedited by Michael J. Barratt, Donald E. Frail.
260			_aHoboken : _bJohn Wiley & Sons, _cc2012.
300			_axx, 477 p. : _bill.
504			_aIncludes bibliographical references and index.
505	0		_aDrug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
533			_aElectronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
650		0	_aPharmaceutical industry _xEconomic aspects.
650		0	_aDrugs _xEconomic aspects.
655		4	_aElectronic books.
700	1		_aBarratt, Michael J.
700	1		_aFrail, Donald.
710	2		_aProQuest (Firm)
856	4	0	_uhttps://ebookcentral.proquest.com/lib/bacm-ebooks/detail.action?docID=938848 _zClick to View
999			_c79820 _d79820