| 000 | 09871nam a22004333i 4500 | ||
|---|---|---|---|
| 001 | EBC6191312 | ||
| 003 | MiAaPQ | ||
| 005 | 20240122001212.0 | ||
| 006 | m o d | | ||
| 007 | cr cnu|||||||| | ||
| 008 | 231124s2020 xx o ||||0 eng d | ||
| 020 |
_a9783030389345 _q(electronic bk.) |
||
| 020 | _z9783030389338 | ||
| 035 | _a(MiAaPQ)EBC6191312 | ||
| 035 | _a(Au-PeEL)EBL6191312 | ||
| 035 | _a(OCoLC)1152535309 | ||
| 040 |
_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ |
||
| 050 | 4 | _aTD193-193.5 | |
| 100 | 1 | _avon Gleich, Arnim. | |
| 245 | 1 | 0 |
_aGene Drives at Tipping Points : _bPrecautionary Technology Assessment and Governance of New Approaches to Genetically Modify Animal and Plant Populations. |
| 250 | _a1st ed. | ||
| 264 | 1 |
_aCham : _bSpringer International Publishing AG, _c2020. |
|
| 264 | 4 | _c�2020. | |
| 300 | _a1 online resource (264 pages) | ||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 505 | 0 | _aIntro -- Acknowledgements -- Introduction -- Contents -- Contributors -- Abbreviations -- Species List -- 1 Technology Characterisation -- Introduction -- SPAGE-Techniques -- Gene Drives -- Methodology of Technology Characterisation -- Depth of Intervention (Technological Power and Range) -- Intensity of Intervention (Number/Frequency) -- Reliability of the Technology -- Corrigibility or Limitation of Damage in Case of Failure -- Important Preliminary Remarks -- SPAGE Technologies -- Release of Insects Carrying a Dominant Lethal Gene (RIDL) -- Meiotic Drives (MD) in particular X-Shredder -- Killer-Rescue -- Maternal-Effect Dominant Embryonic Arrest (Medea) -- Underdominance (UD) -- Homing Endonuclease Genes (HEG) -- CRISPR/Cas9 -- Summary of the Technology Characterisation -- References -- 2 Gene Drives Touching Tipping Points -- The Relevance of Tipping Points to Understand Implications of Deliberate Release of Self Propagating Artificial Genetic Elements (SPAGE) -- Conceptual Background: Phase Transitions in Dynamic Systems -- Examples in Different Scientific Domains -- Concepts and Applications in Dynamic Theory: Important Forms of Phase Transitions Where Tipping Points Mark Domain Boundaries -- Potential Tipping Points with SPAGE Involvement -- A Hierarchy in Consideration Levels: Where SPAGE-Related Tipping Points Could Occur -- Tipping Points on the Molecular and Physiological Level -- Tipping Points on the Population Level -- Tipping Points on the Ecosystem Level -- Tipping Points on the Landscape and (Cross-) Regional Level -- Tipping Points in an Evolutionary Context -- Tipping Point Considerations with Regard to a Social Ecological Domain of SPAGE-The Interaction of Natural and Social Processes -- Tipping Points in Application and Feasibility Considerations -- Tipping Points in Risk Assessment and Management. | |
| 505 | 8 | _aTipping Points in Regulation and Law Enforcement -- Tipping Points in Social Acceptance -- Discourse Outlook -- References -- 3 Vulnerability Analysis of Ecological Systems -- Introduction -- Ecosystem Vulnerability Analysis -- Exposure -- Sensitivity -- Adaptive Capacity -- Event-Based Analysis of Vulnerability -- Potential Tipping Events Caused by GDO -- Structural Analysis of Vulnerability -- Resilience of Ecosystems -- Regime Shifts and Resilience -- Summary -- References -- 4 Case Study 1: Olive Fruit Fly (Bactrocera oleae) -- Population Biology -- Phenology -- Population Characteristics -- Environmental Tolerances -- Dispersal Dynamics -- Dispersal Distances -- Genetic Variability and Gene Flow -- Potential Hazards with Regard to Gene Drive Release -- Unintentional Long-Distance Transport of the Genetically Modified Organism -- Hybridization and Horizontal Gene Transfer Across Species Boundaries -- Ecological Niche Filling by Other Species -- Concluding Remark -- References -- 5 Case Study 2: Oilseed Rape (Brassica napus L.) -- Intention and Scope of the Case Study Oilseed Rape (Brassica napus) -- Oilseed Rape-Biological and Ecological Characteristics -- Production, Uses and Genetic Modification -- Potential Hybridisation Partners -- Conclusions on Gene Flow Potential -- Pests and Pathogens -- Pollen Transfer and Gene Flow -- Gene Flow by Airborne Pollen Transport -- Lineage-Specific Factors of Actual Gene Flow -- Not-Lineage-Specific Factors of Actual Gene Flow -- Gene Flow via Pollen Transport by Insects -- Seed Persistence and Germination in Oilseed Rape -- Genetic Modifications in Oilseed Rape -- Persistence of Genetically Modified Oilseed Rape Outside Fields -- General Implications -- Agricultural Implications -- Conservation Implications -- Detection of Unintended Spread of Transgenic Oilseed Rape in Various Countries. | |
| 505 | 8 | _aModelling Approaches for Gene Drives -- GeneSys -- GeneTraMP -- Model Suitability to Represent Gene Drive Population Dynamics -- Suitability and Prerequisites of Oilseed Rape for Gene Drives? -- Purposes for Oilseed Rape Gene Drives? -- Gene Drives to Delete/Block Herbicide Resistances -- CRISPR/Cas-Based Approaches -- Resistance Blocking -- Overwriting Various Herbicide Resistances with a Single Resistance -- Self-Limiting CRISPR/Cas-Based Approaches -- Gene Drive Seeds as a Breeding Tool on Agricultural Fields -- Female Infertility Drive -- Other Gene Drive Techniques Besides CRISPR/Cas -- Conclusion -- References -- 6 Model Concepts for Gene Drive Dynamics -- Introduction -- Stock-Flow Model of an Olive Fly Population -- Stock-Flow Model of a Single-Locus Underdominance Gene Drive -- Stock-Flow Model of a Medea Gene Drive -- Deterministic Recurrence-Based Calculations on the Inheritance Schemes of Different Gene Drive Techniques -- Stochastic Model Considering an Olive Fly Population with Gene Drive and Bottlenecks -- Differential Equation-Based Modelling of an Olive Fly Population with a Gene Drive -- Individual-Based Model of an Olive Fly Population with Gene Drive -- Conclusion -- References -- 7 Alternative Techniques and Options for Risk Reduction of Gene Drives -- Introduction -- Intrinsic Containment -- Safety Options for GDO-Releases -- Molecular Modifications of Gene Drives as Safety Strategy -- Limitation by Secondary Releases -- Limitation by Dependence -- Limitation by Genetic Instability -- Alternative Approaches to Synthetic Gene Drives -- Overview of Potential Safety Mechanisms -- Summary -- References -- 8 Limits of Knowledge and Tipping Points in the Risk Assessment of Gene Drive Organisms -- Introduction -- The Production of Knowledge and Non-knowledge -- The Science of Non-knowledge in Upstream Technology Assessment. | |
| 505 | 8 | _aThe Exploration of Non-knowledge in the Field of Biotechnology -- Some 'Known Unknowns' in Regard to Risk Assessment of GE Organisms and New Challenges Posed by Gene Drives -- Conceptual Challenges in Risk Assessment of GE Organisms -- Specific Characteristics of GE Organisms -- Specific Challenges in Risk Assessment of Gene Drives -- Some Reasons for Concern Arising from Existing Evidence -- The EFSA Concept and the Problem of Spatio-Temporal Complexity -- The Current EFSA System and Its Approach to Future Applications -- Some Relevant Aspects of Spatio-Temporal Complexity -- Problems Emerging from Spatio-Temporal Complexity for Risk Assessment -- 'Spatio-Temporal Controllability' as a Cut-Off Criterion -- Lessons Learned from Risk Assessment of Chemicals -- Cut-Off Criteria in the Risk Assessment of GE Organisms -- Case Studies: How to Apply 'Spatio-Temporal Controllability' in Practice -- The Role of the Risk Manager -- Discussion -- Conclusions -- References -- 9 Steps Towards a Precautionary Risk Governance of SPAGE Technologies Including Gene-Drives -- Reasons for Concern as an Interface Between Risk Assessment and Risk Management -- Dealing with Non-knowledge: Precautionary, Prospective Technology Assessment Versus Environmental Risk Assessment -- Depth of Intervention -- Identification of Substances of Very High Concern in REACH -- Operationalization of the Precautionary Principle in the Governance of GMOs Along the Lines of REACH -- Conclusion -- Five Steps Towards Integrating the Precautionary Principle into the Governance of SPAGE -- References -- Summary -- References -- Index. | |
| 588 | _aDescription based on publisher supplied metadata and other sources. | ||
| 590 | _aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2023. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. | ||
| 655 | 4 | _aElectronic books. | |
| 700 | 1 | _aSchr�oder, Winfried. | |
| 776 | 0 | 8 |
_iPrint version: _avon Gleich, Arnim _tGene Drives at Tipping Points _dCham : Springer International Publishing AG,c2020 _z9783030389338 |
| 797 | 2 | _aProQuest (Firm) | |
| 856 | 4 | 0 |
_uhttps://ebookcentral.proquest.com/lib/bacm-ebooks/detail.action?docID=6191312 _zClick to View |
| 999 |
_c305706 _d305706 |
||