TY - BOOK AU - Peters,Sheila Annie ED - ProQuest (Firm) TI - Physiologically-based pharmacokinetic (PBPK) modeling and simulations: principles, methods, and applications in the pharmaceutical industry AV - RM301.5 .P48 2011 U1 - 615/.7 23 PY - 2011/// CY - Hoboken, N.J. PB - Wiley KW - Pharmacokinetics KW - Mathematical models KW - Drugs KW - Design KW - Electronic books N1 - Includes bibliographical references and index; Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain; Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries UR - https://ebookcentral.proquest.com/lib/bacm-ebooks/detail.action?docID=818462 ER -