High-throughput screening methods in toxicity testing

High-throughput screening methods in toxicity testing [electronic resource] / edited by Pablo Steinberg. - Hoboken, N.J. : Wiley, 2013. - xv, 552 p., [16] p. of plates : ill. (some col.)

Includes bibliographical references and index.

pt. 1. General aspects -- pt. 2. High-throughput assays to assess different cytotoxicity endpoints -- pt. 3. High-throughput assays to assess DNA damage and carcinogenesis -- pt. 4. High-throughput assays to assess reproductive toxicity, cardiotoxicity, and haematotoxicity -- pt. 5. High-throughput assays to assess drug metabolism and receptor-related toxicity.

"High-throughput assays are part of a paradigm shift, to more cost-effective and reliable methods, in the testing of chemical and drug safety. This book covers methods, data generation, data analysis, and applications in risk assessment for major toxicological assays to help toxicologists apply and understand the benefits and limits of high-throughput testing assays. Each chapter describes method principles and includes detailed information on data generation, data analysis, and applications in risk assessment. The topic is especially timely given Europe's REACH legislation and the US National Research Council"--


Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

9781118538180 (electronic bk.)




High throughput screening (Drug development)
Toxicity testing.


Electronic books.

RS419.5 / .H542 2013

615.1/9